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3b, the PMI, PKG, PTA, and PTK hydrogels did not show cytotoxicity to BMSCs, and more than 90% cell viability was achieved in all the experimental groups compared with the control group, indicating the ideal cytocompatibility of PMI-based hydrogels

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Hypoxia enhances glycolytic flux by upregulating GLUT1/LDHA, and intracellular lactate accumulation triggers p300-induced histone H3K18 lactylation modification, directly regulating arginase-1 (ARG1) expression to suppress CD8 + /CD4 + T cell activity and promote tumor immune escape